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Oxycodone/paracetamol, sold under the brand name Percocet among others, is a combination of the opioid oxycodone with paracetamol, used to treat moderate to severe short-term pain. Percocet tablets are available in four combinations of oxycodone hydrochloride with 325mg of paracetamol (acetaminophen), each having different appearances and usual maximum daily doses. Due to the liver toxicity of paracetamol, the manufacturer and FDA dosage guidelines suggest no more than 4,000 mg total of paracetamol be taken per day, which would be 12 or fewer Percocet tablets per day as each one contains 325mg.
This combination medication is used to help relieve moderate to severe pain. It contains an opioid pain reliever (oxycodone) and a non-opioid pain reliever (acetaminophen). Oxycodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever.
Percocet is a combination of two pain-relieving drugs: acetaminophen and oxycodone. Percocet is available in several strengths, all with 10/325mg acetaminophen and with different dosages of oxycodone: 2.5mg, 5mg, 7.5mg, and 10mg
Acetaminophen is:
Oxycodone is:
An opioid medication that is one of many narcotic substances synthesized from the opium poppy. Similar to drugs such as morphine, heroin, codeine, etc. A controlled substance and considered a Schedule II drug by the United States Drug Enforcement Administration, indicating that it has a very high potential for dependence and abuse despite its medical use.
The acetaminophen in Percocet is the same active ingredient in Tylenol and similar to other over-the-counter painkillers, such as ibuprofen and aspirin. It enhances the pain-relieving effects of oxycodone. Although it does not contribute significantly to the abuse potential of Percocet, acetaminophen can cause liver toxicity if it is taken in large doses over a long period of time.
The oxycodone in Percocet is responsible for both the euphoric effects that individuals experience when taking the drug and the physical dependence and abuse potential of the drug. These effects are achieved by the affinity for oxycodone to lock onto certain receptors of endogenous opioid neurons in the brain and produce similar effects to endogenous opioid neurotransmitters.
The short-term effects of taking Percocet will typically last 4-6 hours and include pain relief, mild euphoria, and mild feelings of sedation, dizziness, lightheadedness, etc.
Percocet is a tablet formulated in several different strengths, and it’s prescribed to treat moderate to significant pain. Due to the high abuse and addiction rates of this drug, the prescribing information for Percocet states that this product is generally reserved for use in those who are already opioid-tolerant or who may not obtain relief from alternative methods.
Opioid abuse is a global epidemic. The National Institute on Drug Abuse (NIDA) publishes that between 26.4 million and 36 million people abuse opioid drugs worldwide. These drugs impact brain chemistry and create a desirable, pleasurable, and relaxing “high,” making them extremely addictive.
Opioid overdose rates are at an all-time high. The Centers for Disease Control and Prevention (CDC) reports that 91 people die every day from an opioid overdose, including from both prescription opioids and heroin. Thankfully, addiction involving opioids is a treatable disease. With a combination of pharmacological, supportive, and behavioral treatments, provided by highly trained professionals in a specialized facility, the chances of long-term recovery are enhanced.
As a powerful narcotic, Percocet works by binding to opioid receptors in the brain, thus blocking pain sensations. It also increases levels of the neurotransmitter dopamine in the brain and depresses functions of the central nervous system. Dopamine is responsible for feelings of pleasure, and opioid drugs like Roxicet interfere with normal levels, creating a euphoric high when the drug is abused.
A large number of potential side effects have been listed for Percocet. The most common side effects from taking Percocet include:
Constipation.
Nausea. Drowsiness. Dizziness or lightheadedness. Dry mouth. Blurred vision.
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Ringing or buzzing in the ears.
Fainting spells. Extremely shallow breathing. Significantly slowed heart rate. Difficulty urinating. Dark urine. Upper stomach pain. Itching (may indicate an allergic reaction). Jaundice (yellow skin or eyes). Nightmares. Confusion. Unusual thoughts. Hallucinations. Delusions. Seizures.
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Oxycodone is an opioid medication used for treatment of moderate to severe pain. It is highly addictive and is commonly used recreationally by people who have an opioid use disorder. It is usually taken by mouth, and is available in immediate-release and controlled-release formulations.
Oxycodone extended-release capsules or tablets should not be used if you need pain medicine for just a short time, such as when recovering from surgery. Do not use this medicine to relieve mild pain, or in situations when non-narcotic medication is effective. This medicine should not be used to treat pain that you only have once in a while or "as needed". v
Oxycodone (sold under the brand names Roxicodone and OxyContin, which is the extended release form, among others) is an opioid medication used for treatment of moderate to severe pain. It is highly addictive and is commonly used recreationally by people who have an opioid use disorder. It is usually taken by mouth, and is available in immediate-release and controlled-release formulations. Onset of pain relief typically begins within fifteen minutes and lasts for up to six hours with the immediate-release formulation. In the United Kingdom, it is available by injection. Combination products are also available with paracetamol (acetaminophen), ibuprofen, naloxone, naltrexone, and aspirin.
Oxycodone was first made in Germany in 1916 from Thebaine. It is available as a generic medication. In 2018, it was the 48th most commonly prescribed medication in the United States, with more than 16 million prescriptions. A number of abuse-deterrent formulations are available, such as in combination with naloxone or naltrexone.
Oxycodone is used for managing moderate to severe acute or chronic pain when other treatments are not sufficient. It may improve quality of life in certain types of pain. It is unclear if use in chronic pain results in improved quality of life or ongoing pain relief.
Oxycodone is available as a controlled-release tablet, intended to be taken every 12 hours. A July 1996 study independent of Purdue Pharma, the drug's originator, found the controlled-release formulation had a variable duration of action ranging from 10 to 12 hours. A 2006 review found that controlled-release oxycodone is comparable to immediate-release oxycodone, morphine, and hydromorphone in management of moderate to severe cancer pain, with fewer side effects than morphine. The author concluded that the controlled-release form is a valid alternative to morphine and a first-line treatment for cancer pain. In 2014, the European Association for Palliative Care recommended oxycodone by mouth as a second-line alternative to morphine by mouth for cancer pain.
In the U.S.A, extended-release oxycodone is approved for use in children as young as eleven years old. The approved uses are for the relief of cancer pain, trauma pain, or pain due to major surgery, in children already treated with opioids, who can tolerate at least 20mg per day of oxycodone; this provides an alternative to Duragesic (fentanyl), the only other extended-release opioid analgesic approved for children.
Common side effects include euphoria, constipation, nausea, vomiting, loss of appetite, drowsiness, dizziness, itching, dry mouth, and sweating. Severe side effects may include addiction, dependence, hallucinations, respiratory depression (a reduction in breathing), bradycardia, and low blood pressure. Those allergic to codeine may also be allergic to oxycodone. Use of oxycodone in early pregnancy appears relatively safe. Opioid withdrawal may occur if rapidly stopped. Oxycodone acts by activating the μ-opioid receptor. When taken by mouth, it has roughly 1.5 times the effect of the equivalent amount of morphine.
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Adderall is are trade names for a combination drug containing four salts of amphetamine. The mixture is composed of equal parts racemic amphetamine and dextroamphetamine, which produces a (3:1) ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. Both enantiomers are stimulants, but differ enough to give Adderall an effects profile distinct from those of racemic amphetamine or dextroamphetamine, which are marketed as Evekeo and Dexedrine/Zenzedi, respectively.
Adderall is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used as an athletic performance enhancer, cognitive enhancer, appetite suppressant, and recreationally as an aphrodisiac and euphoriant. It is a central nervous system (CNS) stimulant of the phenethylamine class.
Adderall is generally well tolerated and effective in treating the symptoms of ADHD and narcolepsy. At therapeutic doses, Adderall causes emotional and cognitive effects such as euphoria, change in sex drive, increased wakefulness, and improved cognitive control. At these doses, it induces physical effects such as a faster reaction time, fatigue resistance, and increased muscle strength. In contrast, much larger doses of Adderall can impair cognitive control, cause rapid muscle breakdown, provoke panic attacks, or induce a psychosis (e.g., paranoia, delusions, hallucinations). The side effects of Adderall vary widely among individuals, but most commonly include insomnia, dry mouth, loss of appetite, and weight loss. The risk of developing an addiction or dependence is insignificant when Adderall is used as prescribed at fairly low daily doses, such as those used for treating ADHD; however, the routine use of Adderall in larger daily doses poses a significant risk of addiction or dependence due to the pronounced reinforcing effects that are present at high doses. Recreational doses of amphetamine are generally much larger than prescribed therapeutic doses, and carry a far greater risk of serious adverse effects.
The two amphetamine enantiomers that compose Adderall (levoamphetamine and dextroamphetamine) alleviate the symptoms of ADHD and narcolepsy by increasing the activity of the neurotransmitters norepinephrine and dopamine in the brain, which results in part from their interactions with human trace amine-associated receptor 1 (hTAAR1) and vesicular monoamine transporter2 (VMAT2) in neurons. Dextroamphetamine is a more potent CNS stimulant than levoamphetamine, but levoamphetamine has slightly stronger cardiovascular and peripheral effects and a longer elimination half-life than dextroamphetamine.
The levoamphetamine component of Adderall has been reported to improve the treatment response in some individuals relative to dextroamphetamine alone.[citation needed] Adderall's active ingredient, amphetamine, shares many chemical and pharmacological properties with the human trace amines, particularly phenethylamine and N-methylphenethylamine, the latter of which is a positional isomer of amphetamine. In 2018, Adderall was the 24th most commonly prescribed medication in the United States, with more than 25 million prescriptions.
Dopamine is directly related to feelings of happiness. For instance, when a person eats something they like, dopamine is released, telling the brain to feel pleasure. This forms a reward pathway. Normally, dopamine is reabsorbed back into receptors in the brain and released again when something pleasurable stimulates that release. Adderall floods the brain with dopamine and prevents it from being reabsorbed quickly.
Adderall works by increasing levels of dopamine, serotonin, and norepinephrine in the brain. Dopamine is one of the brain’s chemical messengers, or neurotransmitters, that sends signals throughout the central nervous system, helping to regulate moods, movement, thinking, learning, and memory functions.
In high amounts, the drug can be considered neurotoxic, as the dopaminergic system is damaged by the drug’s disruption. The journal Molecular Psychiatry warns that prolonged exposure of the brain to the amphetamine contained in Adderall can have neurotoxic effects. This may occur because high levels of dopamine can cause the brain to actually strip itself of dopamine receptors in an effort to “balance” itself.
When levels of dopamine drop after the drug wears off and is no longer active in the bloodstream, less dopamine can be produced and reabsorbed naturally. This can make it difficult for a person to then feel happiness without Adderall. Fatigue, appetite changes, trouble sleeping, depression, anxiety, panic attacks, irritability, agitation, tremors, trouble concentrating and thinking straight, memory lapses, disruption of motor control, stomach upset, and lethargy are all possible side effects of an Adderall comedown when the drug processes out of the body.
Even medically approved use of Adderall can cause side effects; abusing the drug, however, can cause side effects to occur with higher frequency and intensity. Common symptoms of abuse include:
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Continued use can lead to more severe effects. With long-term abuse or abuse that involves high doses of Adderall, the symptoms can compound and lead to even more dangerous effects. These effects include:
Weakness or numbness in the arms or legs.
Dizziness. Slowed or difficult speech. Chest pain. Hives or rash. Blistering or peeling skin Changes in vision. Aggressive behavior. Paranoia. Mania. Seizures.
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Soma is a type of pain medicine that physicians tend to provide to patients who complain about muscle spasms, muscle pain, and related conditions.
The Soma drug is classified as a centrally acting muscle relaxant. While it is known that the medication is effective at producing a reduction in levels of muscle pain that a patient may be experiencing, medical experts do not seem to have a 100% accurate explanation of how exactly the drug works to produce these effects. The most common suggestion is that the active compounds alter how nerves communicate with some regions of the human brain. In turn, this can help to reduce pain sensations.
Soma muscle relaxer is a brand-name prescription drug. While this is the most common brand name that patients are provided with when they complain about muscle pain, there are other names by which the medication is also known.
Soma is a generic name of Carisoprodol pill is essentially the generic or “actual” name for the drug. There are a couple of countries that also sell medicine under the name “CariSoma.”
It should be noted that, due to the addiction potential of the drug, some people have started to sell this medication on the street.
It has led to several “street names” for the drugs being created. Ds and Dance are the most common street names used for Soma drug.
The medication comes in the form of a tablet that is taken orally. A typical prescription strength would be a Carisoprodol or Soma 350mg tablet, but the dosage would depend on the patient that is receiving treatment.
The Food and Drug Administration of the United States has officially approved the use of Soma medicine in patients who suffer from muscle pain and muscle spasms. The FDA has not provided approval for any other purposes for the particular drug.
Longer-term use leads to a higher risk of dependence and an increase in the Carisoprodol withdrawal that may occur when the patient stops using the medicine.
Soma causes sleepiness, giddiness, and feelings of relaxation, so some people use it illicitly to get these effects. Some people who use Soma become addicted to this drug. People who are addicted to Soma may require more and more of it to get the same effect as they used to get with their initial use, and they might experience withdrawal symptoms and cravings for the drug when they stop using it. The U.S. Food and Drug Administration recommends that patients only take Soma for two to three weeks at a time to help prevent drug addiction. Both legitimate users and abusers may experience Soma overdose symptoms if they take more of this drug drug than their bodies can handle.
The number of people who visited the emergency room because of misuse or abuse of carisoprodol doubled between 2004 and 2009, according to the U.S. Substance Abuse and Mental Health Services Administration.
People who mix Soma with other drugs may be at higher risk for an overdose or dangerous side effects. Combining Soma with alcohol increases the drowsiness and dizziness commonly experienced by users. This can lead to accidents, including car accidents and household accidents. According to the National Drug Intelligence Agency, drugs commonly used in combination with Soma include hydrocodone, codeine, alcohol, diazepam, heroin, meprobamate and propoxyphene. Individuals who mix other substances with Soma may experience additional overdose symptoms or may develop Soma overdose symptoms more quickly than they would if using Soma alone. According to the U.S. Substance Abuse and Mental Health Services Administration, about 77 percent of ER visits related to carisoprodol misuse between 2004 and 2009 involved one or more other prescription drugs in addition to carisoprodol.
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Is Soma Addictive?
Soma medication was once considered a safe option for the treatment of muscle-related pain. Still, many reports have recently surfaced regarding the high addictive risk of the chemicals found in the substance.
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Hydrocodone (brand names include Anexsia, Vicodin, Vicoprofen, Norco) is an opioid painkiller medication that is available by prescription. It is the most frequently prescribed opioid analgesic in the United States, and it is diverted and abused at a higher rate than any other legal or illicit opioid 1. In 2011, nearly 30,000 emergency department visits involved the use of hydrocodone, and these numbers have shown an increasing trend 2,3.
Hydrocodone is a medication used to treat pain. It belongs to a group of medications called opioids. Opioids are sometimes called narcotics. Some commonly used hydrocodone products also contain other medications, such as acetaminophen. These include the brand names Lortab, Norco and Vicodin.
Hydrocodone abusers put themselves at high risk of overdose, which can be fatal—nearly 18,000 people died of an opioid medication overdose in 2015 alone 4. Knowing how to identify the symptoms of a hydrocodone overdose may save your life or that of someone you love.
Hydrocodone acetaminophen (generic for Vicodin, Lortab, Norco) is a narcotic analgesic used to treat pain. The drug received renewed attention after Darvon and Darvocet were removed from the market on November 19, 2010. As pain medications are removed from the market, fewer options remain for the treatment of chronic pain.
Vicodin, which was discontinued in the U.S. market, was a popular alternative for some Darvocet-users. Vicodin, which was available in tablet form, to be taken orally (by mouth) contained 5 milligrams (mg) hydrocodone bitartrate and 500mg. There were also Vicodin-ES (7.5 mg hydrocodone bitartrate/750 mg acetaminophen) and Vicodin-HP (10 mg hydrocodone bitartrate/660 mg acetaminophen).
Hydrocodone, sold under the brand name Zohydro ER, among others, is an opioid used to treat severe pain of a prolonged duration, if other measures are not sufficient. It is also used as a cough suppressant in adults. It is taken by mouth.
In 2014, the U.S. Food & Drug Administration (FDA) applied stricter restrictions on hydrocodone-containing products to improve safety and combat prescription pain medication abuse.
The FDA has limited the amount of acetaminophen to 10/325mg per tablet in hydrocodone-containing products and other prescription combination drugs containing acetaminophen in order to prevent overdoses of acetaminophen.1 The FDA has also changed hydrocodone-containing products from schedule III to II which affects how the drugs can be prescribed and obtained.
Hydrocodone/acetaminophen is prescribed to relieve moderate to moderately severe pain. Researchers believe that the ingredient hydrocodone relieves pain by changing how the brain and nervous system respond to painful stimuli.
The dosage of hydrocodone/acetaminophen should be adjusted under the close supervision of your prescribing provider, without exceeding the total allowable daily dosage. With continued use, tolerance to hydrocodone can develop, and with increased dosage, there may be increased side effects.
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Some of the common side effects that may be associated with hydrocodone/acetaminophen include
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Like any prescription drug, Dilaudid is beneficial when used as instructed by a medical professional. When misused, the risk of danger can increase exponentially. Potential side effects of Dilaudid include:
Sensitivity to pain, which can include headaches, migraines, and muscle aches, Gastrointestinal upset, such as constipation, cramps, trouble with digestion, loss of appetite, nausea, vomiting, Dizziness, Drowsiness, Anxiety, Slowed breathing, Seizures, Erectile dysfunction
There are also risks associated with the use of other substances while under the influence of opioid painkillers. Because Dilaudid is a sedative that slows heart rate and reduces lung function, mixing it with other central nervous system depressants (such as alcohol, Valium, and Xanax) could increase the potential for respiratory and cardiac arrest.
To counter developing tolerances and reach a “high” state faster, some individuals bypass taking the medication orally and instead crush pills. The powder is mixed in a solution and injected into the body. This approach can reduce the time it takes to reach peak effect. However, this comes with its own risks, which include infection at the injection site, tissue damage from poor needle placement, or communicable diseases (like hepatitis and HIV) from sharing needles.
An estimated 1 out of 5 patients with pain not associated with cancer or pain-related diagnoses are prescribed opioids during a clinical setting. Data from the National Survey on Drug Use and Health show that while Dilaudid is never used or misused within the overall population, it’s one among the foremost commonly abused opioid drugs taken by chronic opioid users.
Anyone can succumb to the addictive nature of opioids like Dilaudid (Hydromorphone). In fact, regular use of opioids, as prescribed by a doctor, can cause misuse. While Hydromorphone use among the overall population is low (.09%) compared to other opioids, the share of misuse is high. within the chart above, we see that among all opioid users, 10.5% report intentionally misusing Hydromorphone.
Use and misuse of opioids overall have increased dramatically in recent years, mainly due to the environmental availability of drugs. Not only has it become more socially acceptable to treat various ailments with medication, but aggressive pharmaceutical marketing – as well as more prescriptions being written than ever before – has made opioids readily available for those seeking to treat pain or other ailments.
Unfortunately, as many as 1 in 4 people who receive prescription opioids for noncancer pain in a primary care setting struggle with addiction. In 2014, nearly 2 million Americans either misused or were dependent on prescription opioids.
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