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What Is Opana
Opana medications is a highly potent opioid analgesic indicated for treatment of severe pain. Pain relief after injection begins after about 5–10 minutes, after oral administration it begins after about 30 minutes, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets.
It was developed in Germany in 1914. It was patented in 1955 and approved for medical use in 1959. In June 2017 the FDA asked Endo Pharmaceuticals to remove its product from the US market. This was in part due to the opioid epidemic in the US, and the fact that a 2012 reformulation failed to stop illicit injection of the drug. Endo responded by voluntarily removing Opana ER from the market a month later. Generic versions of extended-release oxymorphone, such as those manufactured by Amneal Pharmaceuticals, are still available in the US.
Opana Immediate Release is indicated for the relief of moderate to severe pain, such as treatment of acute post surgical pain. For any chronic treatment of pain, clinicians should only consider long term use if there is significant clinical benefit to the patient's therapy that outweigh any potential risk. The first line treatment choices for chronic pain are non-pharmacological and non-opioid agents.
Opana extended-release tablets are indicated for the management of chronic pain and only for people already on a regular schedule of strong opioids for a prolonged period. Immediate-release oxymorphone tablets are recommended for breakthrough pain for people on the extended-release version. Compared to other opioids, oxymorphone has similar pain relieving efficacy.
Opana is a highly addictive opioid painkiller that can also cause physical dependence. Many people abuse it outside of prescription guidelines, increasing the risk of health complications and overdose.
Opana is a semi-synthetic opioid painkiller. Like other opioids, it alters the way the brain perceives pain so the body does not feel it as much. Oxymorphone is a Schedule II controlled substance with a high potential for abuse and addiction.
Like most opiates, oxymorphone is an opioid receptor agonist. It works by binding to the opioid receptors in the gut and nervous system. With that binding, oxymorphone inhibits the transmission of pain signals to the brain.
It also interacts with dopamine and other pleasure signaling chemicals which produce a feeling of relaxation and happiness. Opana is intended for the management of acute pain. It may be prescribed when other pain-relieving drugs fail to offer relief.
Opana works by attaching to nerve receptors in the brain and increasing the body’s threshold to pain. It also changes the way the pain is experienced and perceived. When abused, it creates intense feelings of euphoria and relaxation, as well as pain relief.
Opana medications was sold under the brand name Opana, but in June of 2017, the FDA asked the manufacturer to remove it from the U.S. market due to high rates of abuse and the ongoing opioid epidemic in America. Opana ER was removed from the U.S. market in July of 2017, but doctors may still legally prescribe generic versions of extended-release oxymorphone tablets in the U.S.
Oxymorphone has a high potential for abuse and addiction because it is a very powerful drug. According to the Substance Abuse and Mental Health Services Administration’s (SAMHSA) 2016 National Survey on Drug Use and Health, 18.7 million people (or 6.9 percent of the population) misused prescription drugs like oxymorphone.
Many people may begin using oxymorphone without intending to abuse it, taking it as prescribed by a doctor. But regular use can lead to tolerance, which will make a person feel like they need more of the drug to feel the same effects. As tolerance develops, the risk for Opana addiction increases, and is much more likely to occur.
Physiological and psychological dependence is not uncommon with oxymorphone and anyone who has developed a tolerance or is misusing it should seek professional help immediately.
The symptoms of oxymorphone abuse are similar to that of other opioids with one critical exception. This drug does not create the same level of the euphoria as associated with heroin, oxycodone (OxyContin, Percocet) or hydrocodone (Vicodin, Norco).
People who abuse oxymorphone (Opana) may experience:
drowsiness and relaxation
anxiety hallucinations nausea and vomiting pinpoint pupils dry mouth or difficulty swallowing abdominal pain changes in vision fast or irregular heartbeat red eyes itching
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