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What is Percocet?
Oxycodone/paracetamol, sold under the brand name Percocet among others, is a combination of the opioid oxycodone with paracetamol, used to treat moderate to severe short-term pain. Percocet tablets are available in four combinations of oxycodone hydrochloride with 325mg of paracetamol (acetaminophen), each having different appearances and usual maximum daily doses. Due to the liver toxicity of paracetamol, the manufacturer and FDA dosage guidelines suggest no more than 4,000 mg total of paracetamol be taken per day, which would be 12 or fewer Percocet tablets per day as each one contains 325mg.
This combination medication is used to help relieve moderate to severe pain. It contains an opioid pain reliever (oxycodone) and a non-opioid pain reliever (acetaminophen). Oxycodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever.
Percocet is a combination of two pain-relieving drugs: acetaminophen and oxycodone. Percocet is available in several strengths, all with 10/325mg acetaminophen and with different dosages of oxycodone: 2.5mg, 5mg, 7.5mg, and 10mg
Acetaminophen is:
Oxycodone is:
An opioid medication that is one of many narcotic substances synthesized from the opium poppy. Similar to drugs such as morphine, heroin, codeine, etc. A controlled substance and considered a Schedule II drug by the United States Drug Enforcement Administration, indicating that it has a very high potential for dependence and abuse despite its medical use.
The acetaminophen in Percocet is the same active ingredient in Tylenol and similar to other over-the-counter painkillers, such as ibuprofen and aspirin. It enhances the pain-relieving effects of oxycodone. Although it does not contribute significantly to the abuse potential of Percocet, acetaminophen can cause liver toxicity if it is taken in large doses over a long period of time.
The oxycodone in Percocet is responsible for both the euphoric effects that individuals experience when taking the drug and the physical dependence and abuse potential of the drug. These effects are achieved by the affinity for oxycodone to lock onto certain receptors of endogenous opioid neurons in the brain and produce similar effects to endogenous opioid neurotransmitters.
The short-term effects of taking Percocet will typically last 4-6 hours and include pain relief, mild euphoria, and mild feelings of sedation, dizziness, lightheadedness, etc.
Percocet is a tablet formulated in several different strengths, and it’s prescribed to treat moderate to significant pain. Due to the high abuse and addiction rates of this drug, the prescribing information for Percocet states that this product is generally reserved for use in those who are already opioid-tolerant or who may not obtain relief from alternative methods.
Opioid abuse is a global epidemic. The National Institute on Drug Abuse (NIDA) publishes that between 26.4 million and 36 million people abuse opioid drugs worldwide. These drugs impact brain chemistry and create a desirable, pleasurable, and relaxing “high,” making them extremely addictive.
Opioid overdose rates are at an all-time high. The Centers for Disease Control and Prevention (CDC) reports that 91 people die every day from an opioid overdose, including from both prescription opioids and heroin. Thankfully, addiction involving opioids is a treatable disease. With a combination of pharmacological, supportive, and behavioral treatments, provided by highly trained professionals in a specialized facility, the chances of long-term recovery are enhanced.
As a powerful narcotic, Percocet works by binding to opioid receptors in the brain, thus blocking pain sensations. It also increases levels of the neurotransmitter dopamine in the brain and depresses functions of the central nervous system. Dopamine is responsible for feelings of pleasure, and opioid drugs like Roxicet interfere with normal levels, creating a euphoric high when the drug is abused.
A large number of potential side effects have been listed for Percocet. The most common side effects from taking Percocet include:
Constipation.
Nausea. Drowsiness. Dizziness or lightheadedness. Dry mouth. Blurred vision.
Some rarer but more serious side effects include:
Ringing or buzzing in the ears.
Fainting spells. Extremely shallow breathing. Significantly slowed heart rate. Difficulty urinating. Dark urine. Upper stomach pain. Itching (may indicate an allergic reaction). Jaundice (yellow skin or eyes). Nightmares. Confusion. Unusual thoughts. Hallucinations. Delusions. Seizures.
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